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Low-Dose Naltrexone (LDN) in Scarsdale, NY
Protocol Health prescribes low-dose naltrexone (LDN) off-label at our Scarsdale, NY clinic and by telehealth, after a provider review. The evidence is mixed, and your provider explains it before you decide.
Consultation $249, or $349 with blood work.
LDN is naltrexone prescribed off-label at a fraction of the standard dose; the FDA-approved uses of naltrexone are opioid and alcohol dependence at much higher doses.
Medically reviewed by Richard Dentico, MD, Medical Director
★ 5.0 on Google · 107 reviews (as of October 2026) · Physician-led, family-owned
Our Scarsdale clinic serves Westchester County. Telehealth in NY, NJ, CT, FL and CA.
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Low-Dose Naltrexone (LDN) at Protocol Health
Before you book
What LDN is
Naltrexone is approved for opioid and alcohol dependence at 50 mg. LDN uses it at a small fraction of that dose, where it is thought to calm glial inflammation and briefly raise the body's own endorphins. Some trials have been positive, including a 2013 crossover study, and a 2024 trial in The Lancet Rheumatology was negative, so benefits are still being established.
Who asks about LDN?
Adults with persistent pain or inflammation questions who accept mixed evidence.
- Chronic pain conditions already evaluated
- Not taking opioid medication
- Comfortable with off-label use
The evidence
Mixed, honestly stated.
Positive. A 2013 crossover trial found benefit.
Negative. A 2024 Lancet Rheumatology trial did not.
Opioids. Naltrexone blocks opioids and is not combined with them.
How LDN is prescribed
Off-label. A known drug at a much lower dose than its approved use.
Oral. A pill or tablet.
Review first. Medications, especially opioids, are checked.
Follow-up. Whether it helps enough to continue.
Starting LDN
In the Scarsdale clinic or by telehealth where appropriate.
- Consultation. Condition, medications, goals.
- Review. Evidence and alternatives.
- Prescription. If appropriate.
- Follow-up. Judge the response.
Common questions
Low-Dose Naltrexone (LDN): frequently asked questions
Is LDN FDA-approved?
Naltrexone is FDA-approved for opioid and alcohol dependence at higher doses; LDN is off-label.
Does LDN work?
The evidence is mixed: some trials positive, a 2024 trial negative.
Can I take LDN with opioids?
No. Naltrexone blocks opioids.
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